{
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  "Package": "joint.Cox",
  "Type": "Package",
  "Title": "Joint Frailty-Copula Models for Tumour Progression and Death in\nMeta-Analysis",
  "Version": "3.16",
  "Date": "2022-2-4",
  "Author": "Takeshi Emura",
  "Maintainer": "Takeshi Emura <takeshiemura@gmail.com>",
  "Description": "Fit survival data and perform dynamic prediction under\njoint frailty-copula models for tumour progression and death.\nLikelihood-based methods are employed for estimating model\nparameters, where the baseline hazard functions are modeled by\nthe cubic M-spline or the Weibull model. The methods are\napplicable for meta-analytic data containing individual-patient\ninformation from several studies. Survival outcomes need\ninformation on both terminal event time (e.g., time-to-death)\nand non-terminal event time (e.g., time-to-tumour progression).\nMethodologies were published in Emura et al. (2017)\n<doi:10.1177/0962280215604510>, Emura et al. (2018)\n<doi:10.1177/0962280216688032>, Emura et al. (2020)\n<doi:10.1177/0962280219892295>, Shinohara et al. (2020)\n<doi:10.1080/03610918.2020.1855449>, Wu et al. (2020)\n<doi:10.1007/s00180-020-00977-1>, and Emura et al. (2021)\n<doi:10.1177/09622802211046390>. See also the book of Emura et\nal. (2019) <doi:10.1007/978-981-13-3516-7>. Survival data from\novarian cancer patients are also available.",
  "License": "GPL-2",
  "NeedsCompilation": "no",
  "Packaged": {
    "Date": "2026-06-08 08:13:54 UTC",
    "User": "root"
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  "Repository": "https://takeshiemura1.r-universe.dev",
  "Date/Publication": "2022-02-04 09:10:10 UTC",
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      "date": "2016-10-30"
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      "version": "2.14",
      "date": "2017-11-23"
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    {
      "version": "2.15",
      "date": "2018-05-29"
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      "date": "2019-05-16"
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      "date": "2019-06-12"
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    {
      "version": "3.4",
      "date": "2019-07-18"
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    {
      "version": "3.5",
      "date": "2019-09-08"
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    {
      "version": "3.6",
      "date": "2019-09-17"
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    {
      "version": "3.7",
      "date": "2019-11-20"
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    {
      "version": "3.8",
      "date": "2020-05-25"
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    {
      "version": "3.9",
      "date": "2020-11-04"
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    {
      "version": "3.10",
      "date": "2020-12-08"
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    {
      "version": "3.11",
      "date": "2021-04-24"
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    {
      "version": "3.12",
      "date": "2021-05-13"
    },
    {
      "version": "3.13",
      "date": "2021-06-13"
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    {
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      "date": "2021-07-03"
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      "date": "2021-10-29"
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    "condCox.reg",
    "F.KM",
    "F.prediction",
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    "jointCox.Weibull.reg",
    "M.spline",
    "splineCox.reg",
    "Weibull.simu"
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        "t.death",
        "death",
        "group",
        "CXCL12"
      ],
      "rows": 1003,
      "table": true,
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      "title": "Data on time-to-recurrence and 158 gene expressions for 912 ovarian cancer patients from 4 independent studies.",
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      "file": "dataOvarian1.rda",
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    {
      "page": "joint.Cox-package",
      "title": "Joint Frailty-Copula Models for Tumour Progression and Death in Meta-Analysis",
      "topics": [
        "joint.Cox-package",
        "joint.Cox"
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    },
    {
      "page": "cmprskCox.reg",
      "title": "The Competing Risks Version of Penalized Likelihood Estimation under the Joint Cox Models Between Tumour Progression and Death for Meta-Analysis",
      "topics": [
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    {
      "page": "condCox.reg",
      "title": "Penalized Likelihood Estimation under the Joint Cox Models Between Tumour Progression and Death for Meta-Analysis; A Conditional Copula Approach",
      "topics": [
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      ]
    },
    {
      "page": "dataOvarian",
      "title": "Survival data of 1003 ovarian cancer patients from 4 independent studies.",
      "topics": [
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      ]
    },
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      "title": "Data on time-to-recurrence and 158 gene expressions for 912 ovarian cancer patients from 4 independent studies.",
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      "title": "Prediction of death using the Kaplan-Meier estimator",
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      "title": "Dynamic prediction of death",
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      "title": "Dynamic prediction of death under the joint frailty-copula model",
      "topics": [
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      "title": "Dynamic prediction of death under the joint frailty-copula model (the Weibull baseline hazard functions)",
      "topics": [
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      ]
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    {
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      "title": "Dynamic prediction of death under the joint frailty-copula model",
      "topics": [
        "F.windows"
      ]
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    {
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      "title": "Dynamic prediction of death under the joint frailty-copula model (the Weibull baseline hazard functions)",
      "topics": [
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    },
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      "title": "I-spline basis function",
      "topics": [
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    },
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      "title": "Penalized Likelihood Estimation under the Joint Cox Models Between Tumour Progression and Death for Meta-Analysis",
      "topics": [
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    {
      "page": "jointCox.reg",
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      "topics": [
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      ]
    },
    {
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      "title": "Weibull-based Likelihood Estimation under the Joint Cox Models Between Tumour Progression and Death for Meta-Analysis",
      "topics": [
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      ]
    },
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      "title": "M-spline basis function",
      "topics": [
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      ]
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      "title": "Fitting the Cox model for survival data using a penalized spline model",
      "topics": [
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      ]
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      "page": "Weibull.simu",
      "title": "Simulating data from the Weibull joint frailty-copula model",
      "topics": [
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